Bioprinting, the additive layering of organic tissue, enables the construction of individual organs from patient-specific cells which prevent postoperative immune response. In the thesis, the transplantation of the organ was substituted by the invasive print of tissue into the patient's body. Bone tissue was used as an example to explore how the functionality of an in vivo prosthesis can be optimized by generative processes in order to reduce the recovery time for the patient. The design of the prosthesis is based on an external support structure surrounding an inner core of printed cells.The support structure serves as a structural bone substitute and allows adhesive refixation of muscles. The organic core of osteoblasts and endothelial cells enables accelerated fracture recovery. Through the process of bone remodeling, the prosthesis is successively resorbed and becomes part of the bone.